Roflumilast Reduces Cerebral Inflammation in a Rat Model of Experimental Subarachnoid Hemorrhage
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چکیده
منابع مشابه
CORRELATION BE TWEEN ENDOTHELIAL INJURY AND CEREBRAL VASOSPASM FOLLOWING A DOUBLE SUBARACHNOID HEMORRHAGE IN THE RAT
While a wide array of pathological changes occur in cerebral arteries following subarachnoid hemorrhage (SAH), the most consistent is endothelial damage. Since the endothelium normally modulates reflexes that influence vascular tone, any damage to it may represent a significant contributor to cerebral vasospasm following SAH. This experimental study investigates the correlation between end...
متن کاملA low mortality rat model to assess delayed cerebral vasospasm after experimental subarachnoid hemorrhage.
OBJECTIVE To characterize and establish a reproducible model that demonstrates delayed cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH) in rats, in order to identify the initiating events, pathophysiological changes and potential targets for treatment. METHODS Twenty-eight male Sprague-Dawley rats (250 - 300 g) were arbitrarily assigned to one of two groups - SAH or saline co...
متن کاملCyclosporine A reduces cerebral vasospasm after subarachnoid hemorrhage in dogs.
The double subarachnoid hemorrhage canine model was used to test the prophylactic value of immunosuppression in the prevention of cerebral vasospasm after subarachnoid hemorrhage. Dogs treated with cyclosporine A following the regimen prescribed for organ transplant procedures in patients showed a significant reduction in the severity of angiographic constriction of cerebral arteries. While bas...
متن کامل- Navarro Cerebral edema following experimental subarachnoid hemorrhage
Cerebral edema following experimental subarachnoid hemorrhage. Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 1982 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Stroke doi: 10.1161/01.STR.13.3.368 1982;13:368-379 Stroke. http://stroke.ahajournals.org/content/13/3/368 located on the World ...
متن کاملCerebral vasospasm after subarachnoid hemorrhage: putative role of inflammation.
Cerebral vasospasm is a common, formidable, and potentially devastating complication in patients who have sustained subarachnoid hemorrhage (SAH). Despite intensive research efforts, cerebral vasospasm remains incompletely understood from both the pathogenic and therapeutic perspectives. At present, no consistently efficacious and ubiquitously applied preventive and therapeutic measures are ava...
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ژورنال
عنوان ژورنال: Inflammation
سال: 2017
ISSN: 0360-3997,1573-2576
DOI: 10.1007/s10753-017-0567-8